4465 Hwy 17 Suite 120, Fleming Island, FL 32003

EXO|E Exosomes - Skin Renewal
That Works
at a Cellular Level

If your skin has started to feel dull, uneven, or like it’s just not bouncing back the way it used to, EXO|E exosome therapy might be worth a closer look. At BelleCutis Aesthetics in Fleming Island, FL, Candice Negrete offers this advanced regenerative treatment for people who want to go beyond surface-level skincare and actually support how their skin heals and renews itself.

EXO|E uses exosomes — tiny messenger molecules — to communicate with your skin cells and encourage natural repair processes. It’s a science-forward approach to skin health that pairs well with other treatments or works powerfully on its own.

20+
Years Experience
20+
Treatments
5★
Patient Rating

Signature Treatments

Plated Exosomes

Exosomes are tiny messenger molecules naturally produced by cells. They carry signals that tell surrounding tissue how to behave — when to repair, when to regenerate, when to produce more collagen. Exosome technology harnesses this signaling process in a concentrated, stabilized form that can be applied to the skin to support its natural renewal cycle.

Unlike traditional skincare that works on top of the skin, exosome treatments are designed to communicate *with* your skin cells — making them a meaningful step forward in how we approach skin health and longevity.

At BelleCutis Aesthetics, exosome treatments can be used as a standalone treatment or paired with other services to enhance and extend your results.

What to Expect at Your Appointment

EXO|E exosomes are applied to the skin to deliver concentrated biological signals that help trigger your skin’s own renewal response. The treatment is non-surgical and typically well-tolerated, making it a practical option for people with busy schedules who still want real results.

Here’s a general sense of what your appointment looks like:

Consultation: Candice will review your skin concerns, current routine, and whether EXO|E is the right fit — or if pairing it with another treatment like PRP or Plated exosomes makes more sense for your goals.
Treatment: The exosomes are applied to cleansed skin, often in combination with a microneedling or other delivery method to maximize absorption. Your appointment time will vary based on your specific protocol.
Downtime: Most people experience minimal downtime. Some temporary redness or sensitivity is common and typically resolves within a day or two.
Results: Skin texture, tone, and overall quality can improve gradually over several weeks as your skin responds. Many people notice a cumulative benefit with a series of treatments.

Fleming Island’s warm, humid climate is tough on skin year-round — UV exposure, heat, and environmental factors can quietly accelerate the signs of aging. EXO|E is one way to actively support your skin’s ability to recover and stay resilient in that environment.

Who Is a Good Candidate for EXO|E Exosomes?

EXO|E isn't a one-size-fits-all treatment

But, it does work well for a wide range of skin concerns. You might be a good fit if you’re dealing with:

Uneven skin texture or tone that hasn’t responded well to topical products alone
Fine lines and early signs of aging and you’re looking for a regenerative approach rather than just filler or neuromodulators
Dullness or loss of radiance — especially common with prolonged sun exposure, which is hard to avoid living in Northeast Florida
Skin that feels “stuck” — like it’s not recovering from stress, lack of sleep, or environmental damage the way it used to
Post-procedure recovery support — EXO|E is sometimes used alongside other treatments to help the skin heal more efficiently

If you’re pregnant, nursing, or have certain skin conditions or health considerations, Candice will discuss whether this treatment is appropriate for you during your consultation.

Why Choose BelleCutis Aesthetics for Exosome Therapy in Fleming Island?

What Sets Us Apart

BelleCutis Aesthetics is a boutique practice in Fleming Island, FL — which means you’re not walking into a high-volume clinic where you feel like a number. Candice Negrete built this practice around thoughtful, personalized care, and that shows up in how she approaches every treatment plan.

A few things that set BelleCutis apart:

A curated menu of regenerative treatments. Alongside EXO|E, BelleCutis offers Plated exosomes, Cellenis DermaPRP, regular PRP, and Vamp PDRN — so you have real options when it comes to biostimulation and skin renewal, not just one product pushed on everyone.
Combination treatment expertise. Exosomes often work best when layered strategically with other therapies. Candice can help you think through whether pairing EXO|E with something like InMode Ignite or PRP makes sense for your specific skin goals.
Honest consultations. You’ll get a clear picture of what EXO|E can realistically do for your skin — no overpromising, no pressure.
Convenient Fleming Island location. Located at 4465 US-17, Suite 120, BelleCutis is easy to get to whether you’re coming from Orange Park, Middleburg, or right here on Fleming Island.

Common Questions

Frequently Asked Questions

Have questions before booking? We’ve answered the most common ones below. For anything else, our team is always happy to help.

Exosomes are extracellular vesicles — essentially tiny packages released by cells that carry growth factors, proteins, and signaling molecules. They act like messengers, telling surrounding cells how to behave. PRP (platelet-rich plasma) uses your own blood to deliver growth factors, while exosomes like EXO|E are a cell-free option that delivers a highly concentrated set of biological signals. Both are available at BelleCutis, and Candice can help you decide which approach — or which combination — fits your goals.
This varies depending on your skin and what you’re hoping to address. Some people see meaningful improvement after a single session, while others benefit from a series. Your consultation with Candice will give you a clearer idea of what to expect based on your individual skin.
EXO|E is designed with safety as a priority and is generally well-tolerated. As with any aesthetic treatment, there are considerations based on your personal health history — which is exactly why a thorough consultation matters. Candice will review your health background before recommending any treatment.
Yes — and in many cases, combining treatments produces better outcomes than any single treatment alone. EXO|E pairs well with microneedling, PRP, and other regenerative options available at BelleCutis. Your treatment plan will be built around your specific skin concerns, not a generic protocol.
Both are exosome-based treatments, but they come from different sources and have different formulations. BelleCutis carries both, which allows Candice to recommend the option that’s best suited to your skin type and goals. This is something she’ll walk through with you during your consultation.